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رسالة ماجستير / تضامن حسين


Psoriasis is a  multifactorial and inflammatory skin disease; the etiology is unknown. The  clinical features are  red, dry, itching  and scaly  skin. Lesions results from the hyper proliferation of skin  keratinocyte cells. The  hyper proliferation is caused by cytokines secreted by activation  of  the cells of immune system,  an infiltrate of dendritic cells, T lymphocytes and innate immunity cells  as well as the keratinocytes. A large number of  cytokines have been shown to be  raised in psoriatic lesion and  serum concentrations, also associated with severity of psoriasis.

 The aim of this study was to evaluate the role of TGF-B1, TNF-a and interleukin 10  in psoriasis which could help as predictive marker for severity of psoriasis  in Baquba Teaching Hospital. This study included forty nine  patients with psoriasis (27 males and 22 females) and thirty three healthy individuals (18males and 15 females). The ages of patients range  between (7-70) years and healthy group(10-68) years. The study was performed in Baquba Teaching Hospital  during the period from December 2018 till June 2019.   Each case was diagnosed by dermatologist. Five milliliter of venous blood sample were  obtained from each patient and placed in gel tube to separate the serum  and  stored at -80ºC.

          The results of the study showed that the prevalence of psoriasis vulgaris  in the patients were (89.8%) of cases. Guttat psoriasis were (4.1%), Erythrodermic (4.1%) and Nail psoriasis(2%). The result of TGF-B1  level  showed  highly significant differences in psoriatic  patients than  healthy individuals  Mean±SD  (8.25± 3.66) (P=0.005). Also the level of TNF-a showed very high significant difference in psoriasis patients than controls Mean±SD (52.63± 15.53) (P=0.001).

          While IL-10  level were elevated among patients with psoriasis but insignificant difference between patients and controls Mean±SD (244.46±67.23) (P=0.9)  by using  Enzyme Linked Immunosorbent Assay (ELISA) technique.

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