Abstract
2-Deoxy-2-amino-d-glucose and 6-Deoxy-6-amino-d-glucose were selected as a kind of chemically stable monosaccharides. Its structure, containing multiple functional groups including five hydroxyl groups, an amino group, and an aldehyde group, makes it unique as a precursor for the preparation of nine new 2-deoxy-2-amino-d-glucose compounds by linking it with the monosaccharides glucose, fructose, arabinose, xylose, and ribose, and it was reacted with the disaccharides lactose and maltose. Two new 6-deoxy-6-amino-d-glucose compounds were prepared by linking them with the disaccharides maltose and lactose. Two methods were used to link the sugars, namely Schiff base and Fischer. The characterization and purity of the synthesized derivatives were confirmed by spectroscopic methods, including 1HNMR, FTIR, and 13C-NMR.
The biological results showed that some of the produced molecules are effective as antibacterial agents against two types of Gram-positive bacteria, S. aureus and S. epidermidis, and two types of Gram-negative bacteria, P. aeruginosa and Escherichia coli.
The compounds were also tested [4], [8] on rate after we induced arthritis by injecting the feet with formalin and leaving them for a week, which caused arthritis in them. In comparison with the control group, the effectiveness of the prepared compounds in treating arthritis was shown after 21 days of use.
