New cross-linked polymers (M1-M10) impregnated on drugs were prepared using solution polymerization and free radical polymerization techniques. The drugs were dissolved in acrylic acidic medium. Benzene was then added as a solvent. The cross-linking agent methylene diacrylamide (MBA) was added, and after heating, the initiator (AIBN) was added. The completion of the polymer reaction appears as a precipitate, and its precipitation is completed by adding methanol.
The prepared polymers were characterized using infrared spectroscopy, thermal analysis (TGA), scanning electron microscopy (SEM), and also using Uv-Vis spectroscopy.
The swelling of a specific weight of the polymer was tested, and it was added to a calculated volume of water and methanol. The results showed that the swelling was greater in water than in methanol.
The solubility of polymers was tested using acidic and basic media. The result was that the polymers did not dissolve in all these media. The drug release efficiency of the polymer was measured at pH = 2, which is equivalent to the pH of the stomach, and also at pH = 7.4, which is equivalent to the pH of the small intestine. The result was that the drug was released into the small intestine at a very high rate compared to the stomach, and this result achieved the goal of the research